An independent expert scientific panel reviews all of RIFM’s research, and its conclusions form the basis for the standards set by the International Fragrance Association (IFRA). endobj
The IFRA/RIFM safety program is essentially comprised of four main parts: Peer-reviewed science on fragrance chemicals; Safety assessments conducted by an independent expert panel (REXPAN) A comprehensive database of toxicological data on fragrance chemicals; IFRA standards determining allowable levels of fragrance chemicals to be used in products Information and documents relating to the Code of Practice are available in the About us section of the website. IFRA standards are voluntary. 9 0 obj
The Standards—which also set purity rules or may ban certain ingredients for fragrance applications—are derived from scientific assessments by the Research Institute for Fragrance Materials (RIFM) with independent oversight by the Expert Panel for Fragrance Safety. ���% Based on the RIFM Expert Panel's recommendation, RIFM and IFRA have formally adopted the QRA approach, refined for fragrance ingredients identified as contact allergens, as the core strategy for primary prevention of dermal sensitization to these materials in consumer products. !��Ȉ��]�C������m.1����8�.��ahy�[�㏳>�$_<3s'%� IFRA Environmental Standards and RIFM Program Advances - Update for 2017; Phototoxicity of ethyl vanillin: comparison of two in vitro methods; RIFM's Streamlined Safety Assessment Process; Salicylic acid and toluene diisocyanateenhance carbachol-induced bronchoconstriction in human precision-cut lung slices (hPCLS) The Expert Panel for Fragrance Safety is an independent panel of experts that reviews the activities of the Research Institute for Fragrance Materials (RIFM) for consumers, official agencies, and the industry. [��Az�͆��]ZSH4n�ٕ��?Ꮧ�E�� The IFRA Standards are based on safety assessments by the Panel of Experts of the RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS (RIFM). IFRA Standards Setting Process Find out more by following this link, Template for Certificate of Conformity to the IFRA Standards (DOC), IFRA Information Letter 1107 - Clarifications related to the implementation of IFRA Standards and categorization of product types in the 49th Amendment, Guidance for the use of IFRA Standards - 49th Amendment (PDF), IFRA Information Letter 1089 - Update to implementation deadlines for the 49th Amendment due to COVID-19, IFRA Standards Library - 49th Amendment (ZIP - 43MB), Notification Letter - 49th Amendment (PDF), Annex I to the IFRA Standards - 49th Amendment (XLSX), Annex II to the IFRA Standards - 49th Amendment (XLSX), Index of IFRA Standards - 49th Amendment (PDF), IFRA Standards overview - 49th Amendment (XLSX), IFRA-Cosmetics Europe - Guidelines on Exchange of Information - IFRA Information Letter 977, Supporting our societies: a Sense of Purpose, Inspiring trust: a Sense of Responsibility. 4 0 obj
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The IFRA Standards form the basis for the globally accepted and recognized risk management system for the safe use of fragrance ingredients and are part of the IFRA Code of Practice. Please cite this article in press as: A.M. Api, et al., Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients, Food and Chemical Toxicology (2015), doi: 10.1016/j.fct.2014.11.014 Contents lists available at ScienceDirect FoodandChemicalToxicology As already communicated to the membership by IL1032 and by the several webinars organized by IFRA and RIFM ahead of the consultation, these improvements $0. For more details see chapter 1 of the Guidance for the use of IFRA Standards. %PDF-1.7
Notably, the IFRA QRA product categories for Standards based on sensitization are likely to change with the implementation of the QRA2 and such categories will need to be harmonized with those used in Standards based on endpoints other than skin sensitization. IFRA provides information on the exposure situation (usage concentration, variety of use, volume of use), chemical composition as well as the olfactory profile and olfactory potential (importance) of a fragrance ingredient to the Research Institute for Fragrance Materials (RIFM), the scientific arm of IFRA. Founded in 1966, Research Institute for Fragrance Materials Inc is a nonprofit. 11 0 obj
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When warranted by concerns regarding the safe use of a specific ingredient identified by the RIFM safety assessment program, IFRA will issue an IFRA Standard as part of an IFRA Amendment. Fragrance manufacturers must provide an IFRA Conformity Certificate to their customers to assure them that the standards are being met for any fragrance product they sell. <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 595.32 841.92] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>>
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The standards exist in order to establish safe levels of use for fragrance ingredients as determined by the RIFM safety assessments. This booklet now combines three documents that were previously distributed separately: 1) Introduction to the IFRA Standards; 2) IFRA-RIFM QRA Information Booklet; and 3) Standard Operating Procedure for the Implementation Timelines of Amendments to the IFRA Standards. It is the ultimate responsibility of our customer to ensure the safety of the final product (containing this fragrance) by further testing if need be. Based on the RIFM Expert Panel’s recommendation, RIFM and IFRA have formally adopted the QRA approach, refined for fragrance ingredients identified as contact 8 0 obj
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Due to innovative new uses of fragrances or existing fragrance applications that are considered not (adequately) covered by the QRA Categories in the IFRA Code of Practice, in these cases, companies should request RIFM to review additional information for such uses and assign them to the appropriate QRA Category. 2 DAIg}�dz�][���q$9�ʇ9aF��d��蚛�w�{����@��� 8���Dҭ[_��w���[�����aH>��¦7������dl���x� ���ټ��y����ut�����h�]�R68h_[{d���z��g3�y � �68� By continuing to use the site, you agree to the use of cookies. Evaluation of individual Fragrance ingredients is made according to the safety standards contained in the relevant section of Using the most current, globally-recognized guidelines, RIFM has to date completed panel-approved safety assessments for more than 85% of the current volume of use by the fragrance industry. 6 0 obj
The IFRA categories for dermal sensitization and systemic toxicity endpoints have been revised and harmonized. <>
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IFRA Member companies must comply with the Standards. Criteria for safe use of fragrance ingredients is prescribed within IFRA standards, which can either prohibit, restrict or set purity requirements for specific ingredients based on the findings of the Research Institute for Fragrance Materials (RIFM). ))��TO������T�ɺy�$4������H�R)��g �O�O�������xw������y�d��#R���3������HR*�O "GllbIIkw�uf������� #�f{:;{�_Z��| ��!ّ�[m6/,/?��kRm$�WV�ko_�˫MHH�� @�E�V����^[�A�.��}�a{�r�q:_���x�p�A���_����r���+ɷ�T���O�ս:]�(�x� �zz666�$�*n��C�������kuu����22J��3�����g��%["�H*����M6��@��|�b�-���EE�55���+�㟭�?$q)U�dW��?���� ��h�io_�X����(GG����^��ͭ1�H�����@r���윜ʫW�[[g��\˃�����-/�ѱb2`4 @4 ���Ҷ���ϑ^�����o��=
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The RIFM Expert Panel's conclusions on safe use, based on its critical evaluation of all available safety data and exposure information, form the basis of the IFRA Standards… <>
... for their use in developing the ifra standards to be utilized by the fragrance industry to guarantee the safe use of such materials in products to be distributed to consumers. RIFM's Online Fragrance Material Safety Assessment Resource Center is published by Elsevier's Food and Chemical Toxicology Journal. IFRA standard abstract Significant developments have recently been incorporated in the way dermal sensitization risk assess-ments are conducted for fragrance ingredients. IFRA Environmental Standards and RIFM Program Advances - Update for 2017; Phototoxicity of ethyl vanillin: comparison of two in vitro methods; RIFM's Streamlined Safety Assessment Process; Salicylic acid and toluene diisocyanateenhance carbachol-induced bronchoconstriction in human precision-cut lung slices (hPCLS) 2 0 obj
Together with the industry’s scientific center, RIFM (the Research Institute for Fragrance Materials), IFRA makes sure that usage standards for fragrance materials are put into practice according to the available scientific recommendations. Politano VT, Api AM. endobj
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The latest update represents the most significant change to the Standards in years. 1 0 obj
IFRA STANDARD Tagetes oil and absolute 2020 (Amendment 49) 3/5 IFRA STANDARD not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). 10 0 obj
IFRA member companies must comply with IFRA standards to maintain their membership, but compliance with the standards is almost never verified. 4 May 2020 Guidance for the use of IFRA Standards - 49th Amendment (PDF) 20 September 2020 IFRA-RIFM Categorization Form. 2 March 2021 IFRA Information Letter 1107 - Clarifications related to the implementation of IFRA Standards and categorization of product types in the 49th Amendment. The Research Institute for Fragrance Materials’ Human Repeated Insult Patch Test Protocol. For the 49th Amendment, IFRA Standards reflect the introduction of several improvements of the risk assessment methodology. According to IFRA RIFM QRA Information Booklet (Version 7.1- Revised July 9, 2015): “Based on the chemical, cellular and molecular understanding of dermal sensitization, it is possible to conduct an exposure-based Quantitative Risk Assessment (QRA) to determine safe use levels of fragrance ingredients in a variety of consumer product types. Together with the industry's scientific centre RIFM (the Research Institute for Fragrance Materials), the IFRA team endeavors to make sure that the usage standards for fragrance materials are put into practice according to the available scientific recommendations and … <>
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The 49 th Amendment to the IFRA Code of Practice presents a total of 125 new and revised standards. Then IFRA standards regarding use restrictions are based on safety assessments by the Panel of Experts of RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS (RIFM) and are enforced by the IFRA scientific Committee. RIFM and IFRA RIFM IFRA International scientific institute International trade association Safety data Risk management Safety assessments Standards 7 RIFM Fragrance Material Evaluation RIFM has a long history of developing, reviewing and publishing safety-related scientific data … The assessment currently covers approximately 3,000 distinct materials, with close to 900 of those being natural complex substances (NCS), which make up the IFRA transparency list. Conclusion: Not PBT or vPvB as per IFRA Environmental Standards Risk assessment: Screening-level: PEC/PNEC (North America and Europe) > 1 (RIFM Framework; Salvito et al., 2002) Critical ecotoxicity endpoint: 48 h Daphnia magna EC50: 1.13 mg/l RIFM PNEC is: 1.13 mg/l Revised PEC/PNECs (2011 IFRA VoU): North America and Europe <1 An independent expert scientific panel reviews all of RIFM’s research, and its conclusions form the basis for the standards set by the International Fragrance Association (IFRA). <>
IFRA Standards can either prohibit, restrict or set purity requirements for specific ingredients. The IFRA/RIFM safety program is essentially comprised of four main parts: Peer-reviewed science on fragrance chemicals; Safety assessments conducted by an independent expert panel (REXPAN) A comprehensive database of toxicological data on fragrance chemicals; IFRA standards determining allowable levels of fragrance chemicals to be used in products This is the self-regulating system of the industry, based on risk assessments carried out by an independent Expert Panel. endobj
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The Resource Center features RIFM peer reviewed scientific publications including: The Revised Criteria document for RIFM's Safety Evaluation Process of Fragrance Materials; <>
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